Quantitative assessment of relationship between sequence similarity and function similarity
نویسندگان
چکیده
منابع مشابه
Exploring the relationship between sequence similarity and accurate phylogenetic trees.
We have characterized the relationship between accurate phylogenetic reconstruction and sequence similarity, testing whether high levels of sequence similarity can consistently produce accurate evolutionary trees. We generated protein families with known phylogenies using a modified version of the PAML/EVOLVER program that produces insertions and deletions as well as substitutions. Protein fami...
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BACKGROUND Predicting protein function from primary sequence is an important open problem in modern biology. Not only are there many thousands of proteins of unknown function, current approaches for predicting function must be improved upon. One problem in particular is overly-specific function predictions which we address here with a new statistical model of the relationship between protein se...
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$L$-fuzzy rough sets are extensions of the classical rough sets by relaxing theequivalence relations to $L$-relations. The topological structures induced by$L$-fuzzy rough sets have opened up the way for applications of topological factsand methods in granular computing. In this paper, we firstly prove thateach arbitrary $L$-relation can generate an Alexandrov $L$-topology.Based on this fact, w...
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ABSTRACT Background: The efficacy of anticonvulsants after a first seizure is uncertain the more predictable the time and the type of recunent seizure, the more preventable the probable events. This study was conducted to evaluate sirnilmity of type and time of a first seizure and its recutTence in children. Methods: 174 children with at least two separate seizures were taken into account. Res...
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ژورنال
عنوان ژورنال: BMC Genomics
سال: 2007
ISSN: 1471-2164
DOI: 10.1186/1471-2164-8-222